Thursday, August 6, 2009

Pingie: HTTP:: Immune System Enzymes Sense Viral RNA

HTTP:: Immune System Enzymes Sense Viral RNA
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Experts from Penn State and the University of Connecticut, in the US, and the University of Beijing, in China, have recently discovered the fact that a certain enzyme inside the human immune system is able to detect certain pairs of viral RNA belonging to infecting pathogens. The enzyme, known as protein kinase R (PKR), is regulated differently by common RNA inside the body and the RNA in pathogens, and its changes provide a basis for biologists to assess what kind of infection it might be. “PKR plays an important role in the human immune system. It is activated by long stretches of double-stranded RNA. As a part of our built-in immune response, PKR can recognize viral double-stranded RNAs and inhibit their production,” the first author of the new study, chemistry graduate student Laurie Heinicke, from the Pennsylvania State University (Penn State), explains. “Once activated by certain RNAs, PKR stops protein synthesis in the infected cell and ultimately causes cel!
l death,” she adds, quoted by e! Science News. When infecting a host, viruses are in the nasty habit of injecting their own genetic material inside cells, forcing them to essentially produce more generations of viruses, rather than their usual chemicals. In order for this to happen, viral RNA is released inside the cell. If ...
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http://news.softpedia.com/news/Immune-System-Enzymes-Senses-Viral-RNA-118405.shtml

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