HTTP:: New Cell Adhesion Mechanism Discovered
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In case of an infection, when pathogens pour freely through an open wound inside the body, the immune system must be quick on the spot with its response. Various types of immune cells need to be activated, and all of this must be done within moments of the time when the invading microorganisms were first detected. Failure to do so could lead to widespread infection, a situation that would significantly decrease the defense system's ability to take on whatever pathogen invaded the body. Its efforts must therefore be concentrated as fast as possible, AlphaGalileo reports. Dendritic cells are among the most important ones in the immune system. They are not exactly involved in the cleansing process, but they play a huge role in identifying the pathogens, and in communicating their finds to T-cells, which are one of the body's main weapons against the invaders. The thing that dictates whether a successful response will be mounted or not is the dendritic cells' ability to be cor!
rectly activated, travel to the lymph nodes, and then adhere firmly to the surface of T cells that, in this manner, become aware of the pathogen they are fighting against. The integrin lymphocyte-associated antigen-1 (LFA-1) is primarily responsible for regulating all of these processes. The stable adhesion between the dendritic and T cells c...
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http://news.softpedia.com/news/New-Cell-Adhesion-Mechanism-Discovered-125271.shtml
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