HTTP:: New DNA Cleavage Method Uses Water Molecules
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Experts at the University of Illinois, in the United States, have recently announced the development of a new technique to cleave single-stranded DNA, using newly discovered deoxyribozymes (catalytic DNA). According to the team, the instrument exhibits the sequence-selectivity and the site-selectivity required of a practical catalyst, and may therefore prove to be a sustainable method of manipulating the notoriously hard-to-work-with human DNA. âœOur work suggests that deoxyribozymes have significant potential as sequence-specific DNA cleavage reagents. The hope is that we can take this fundamental advance and develop the ability to use DNA as a practical catalyst to cleave double-stranded DNA,â UI Chemistry Professor Scott Silverman says. Details of the new method, on which postdoctoral research associate Madhavaiah Chandra and graduate student Amit Sachdeva also worked, were accepted for publication in press in an upcoming issue of the journal Nature Chemical Biology, !
and already appear online on the publication's website. The new discovery came somewhat by accident, the team say. Their efforts were not focused on finding a compound that could cleave single-stranded DNA, but on uncovering artificial sequences of DNA that could cleave proteins. However, they found ...
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Monday, August 17, 2009
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