Pingie: HTTP:: Nuclear Pore Complexes Begin to Reveal Their Secrets

HTTP:: Nuclear Pore Complexes Begin to Reveal Their Secrets
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For a long time, scientists have tried to understand the exact construction and operating mechanism of complex protein structures inside cellular nuclei called nuclear pore complexes (NPC). These intricate structures, made up of as much as 30 individual proteins, are extremely large, and yet remained impenetrable to viewing techniques for many years. Now, a new series of studies, from researchers at the Rockefeller University’s (RU) Laboratory of Cell Biology, finally begins to shed some light on the elusive formations, ScienceDaily reports. In order to maintain their integrity, cells are careful about what they let inside their nuclei. This is where all the genetic material is stored, and, if intruders make it through, then viruses and other pathogens can gain a foothold in the organisms. This may start a chain of mutations that could lead to severe diseases such as cancer. NPC are, in fact, transport machines, which only bind to selected series of chemical compounds. !
These chemicals are “known” to be safe, so the NPC carry them. The RU investigation has now revealed the make-up of one of these proteins, as well as the interactions it has with a partner. The study is the first to prove a theory that holds that ring-like structures exist within the pores, around each opening they...
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