Pingie: HTTP:: Tethered Proteins Are Highly Flexible

HTTP:: Tethered Proteins Are Highly Flexible
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The first known genetic regulatory protein, the lactose repressor protein, was discovered as far back as 1966, but it was only recently that the tools of biochemistry became sophisticated enough to allow for it to be investigated thoroughly. Behind the research were experts at the Rice University (RU), who discovered that the shape of proteins, in general, and their structure determined their function. Furthermore, the proteins are highly flexible. The discoveries are detailed in this week's issue of the respected journal Proceedings of the National Academy of Sciences (PNAS). “It's become increasingly clear that many proteins are highly flexible and able to form different types of structures when they interact with something else, often another protein or DNA. That's true for lactose repressor in binding to DNA, making it a good candidate to learn more about the process of DNA looping because it's a relatively simple and well-studied protein,” the RU Stewart Memorial !
Professor of Biochemistry and Cell Biology, Kathleen Matthews, who has also been the co-author of the new PNAS paper, explains. She started studying the lactose repressor protein almost four decades ago. “Our findings are important, but there is clearly more work to be done. We've found that limiting flexibility indeed limits pro...
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